Mac and cheese meatloaf casserole is the ultimate comfort food mash-up your family will crave. Creamy, cheesy macaroni pairs perfectly with juicy, flavorful meatloaf, baked together into one hearty dish. It’s the kind of meal that brings smiles to the table and makes weeknights feel special.

I love sharing recipes that balance simplicity and satisfaction, and this one is always a winner. If you enjoy easy pasta bakes like my creamy sausage rigatoni, this casserole will quickly earn a spot on your dinner rotation. It’s comforting, family-friendly, and guaranteed to impress.

Why You’ll Love This Mac and Cheese Meatloaf Casserole

• It’s a one-dish meatloaf macaroni bake, making cleanup a breeze.
• This cheesy comfort food casserole is packed with flavor and nostalgia.
• It’s quick to prepare, perfect for busy weeknights.
• Family-friendly and sure to please even the pickiest eaters.
• Leftovers are just as delicious, making it great for meal prep!

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Ingredients for Mac and Cheese Meatloaf Casserole

Gathering the right ingredients is key to making this delightful Mac and Cheese Meatloaf Casserole. Here’s what you’ll need:

• Ground Beef: The star of the show! It provides a hearty base for the meatloaf.
• Onion: Diced onion adds a sweet and savory flavor that enhances the meatloaf.
• Breadcrumbs: These help bind the meatloaf together, giving it a nice texture.
• Egg: A crucial ingredient for binding, it keeps everything moist and together.
• Milk: Used in both the meatloaf and cheese sauce, it adds creaminess.
• Salt and Pepper: Essential seasonings that elevate the flavors of the dish.
• Macaroni: The classic pasta that pairs perfectly with the cheesy sauce.
• Cheddar Cheese: The gooey goodness that makes this casserole irresistible!
• Butter: Adds richness to the cheese sauce, making it extra creamy.
• Flour: Used to thicken the cheese sauce, giving it that perfect consistency.
• Paprika: A dash of this spice adds a subtle smokiness and color.
• Dry Mustard: This ingredient gives a slight tang that enhances the cheese flavor.

Feel free to get creative! You can substitute ground turkey or chicken for a lighter option. Different cheeses, like mozzarella or pepper jack, can add a unique twist. For exact quantities, check the bottom of the article where you can find a printable version of the recipe.

How to Make Mac and Cheese Meatloaf Casserole

Now that you have all your ingredients ready, let’s dive into the fun part—making this delicious Mac and Cheese Meatloaf Casserole! Follow these simple steps, and you’ll have a comforting meal that your family will love.

Step 1: Preheat the Oven

First things first, preheat your oven to 350°F (175°C). Preheating is crucial because it ensures that your casserole cooks evenly. No one likes a soggy meatloaf, right? So, let that oven warm up while you prepare the rest of the dish.

Step 2: Prepare the Meatloaf Mixture

In a large bowl, combine the ground beef, diced onion, breadcrumbs, egg, 1/4 cup of milk, salt, and pepper. Use your hands to mix everything together until well combined. You want a nice, cohesive mixture that holds together but isn’t too dense. Think of it like a soft hug for your taste buds!

Step 3: Bake the Meatloaf

Transfer the meatloaf mixture into a greased baking dish, shaping it into a loaf. Bake it in the preheated oven for about 30 minutes. You’ll know it’s done when the internal temperature reaches 160°F (70°C). The edges should be slightly browned, and the center should be firm but not dry.

Step 4: Cook the Macaroni

While the meatloaf is baking, bring a pot of salted water to a boil. Add the macaroni and cook according to the package instructions until al dente. This usually takes about 7-8 minutes. Once cooked, drain the macaroni well, but don’t rinse it! You want that starchy goodness to help the cheese sauce stick.

Step 5: Make the Cheese Sauce

In a saucepan over medium heat, melt the butter. Once melted, stir in the flour and cook for about a minute to create a roux. Gradually whisk in 2 cups of milk, stirring constantly until the mixture thickens. This should take about 5 minutes. Add salt, pepper, paprika, and dry mustard, then stir in the shredded cheddar cheese until it’s all melted and creamy. You’re creating a cheesy comfort food masterpiece!

Step 6: Combine Macaroni and Cheese Sauce

Now, it’s time to bring the macaroni and cheese sauce together. In a large bowl, combine the drained macaroni with the cheese sauce. Mix well until every piece of pasta is coated in that gooey goodness. This is where the magic happens, and your kitchen will start to smell heavenly!

Step 7: Assemble the Casserole

Once the meatloaf is done baking, carefully remove it from the oven. Spread the mac and cheese mixture evenly over the top of the meatloaf. Make sure to cover it completely for that perfect one-dish meatloaf macaroni bake experience. It’s like giving your meatloaf a cozy blanket of cheesy goodness!

Step 8: Final Bake

Return the casserole to the oven and bake for an additional 15-20 minutes. You want it heated through and golden on top. Keep an eye on it; the cheese should be bubbly and slightly browned. Once it’s done, let it cool for a few minutes before serving. This final bake is essential for melding all those flavors together!

Tips for Success

• Use lean ground beef for a healthier option without sacrificing flavor.
• Don’t overmix the meatloaf; a gentle hand keeps it tender.
• Experiment with different cheeses for a unique twist on the classic flavor.
• Let the casserole cool slightly before serving; it helps the layers set.
• For extra flavor, add herbs like parsley or thyme to the meatloaf mixture.

Equipment Needed

• Baking dish: A 9×13 inch dish works perfectly, but any oven-safe dish will do.
• Mixing bowl: A large bowl for combining the meatloaf ingredients.
• Pot: For boiling the macaroni; a medium-sized pot is ideal.
• Whisk: Essential for making the cheese sauce smooth.
• Meat thermometer: To ensure your meatloaf is cooked to perfection.

Variations To Try

• For a spicy kick, add diced jalapeños or a sprinkle of cayenne pepper to the cheese sauce.
• Swap out the ground beef for ground turkey or chicken for a lighter version of this casserole.
• Try using different types of cheese, like pepper jack for a zesty flavor or gouda for a smoky twist.
• Add vegetables like spinach, bell peppers, or mushrooms to the meatloaf mixture for extra nutrition.
• For a gluten-free option, use gluten-free breadcrumbs and pasta to accommodate dietary needs.

Serving Suggestions

• Pair with a fresh garden salad for a refreshing contrast to the rich casserole.
• Serve with garlic bread or crusty rolls to soak up the cheesy goodness.
• A glass of chilled iced tea or lemonade complements the meal perfectly.
• For presentation, sprinkle fresh parsley on top for a pop of color.

FAQs about Mac and Cheese Meatloaf Casserole

Conclusion

This mac and cheese meatloaf casserole is more than just a recipe—it’s a memory-making dish that brings everyone together. With its creamy pasta layer and hearty meatloaf base, it delivers both flavor and comfort in every bite. It’s quick enough for weeknights yet special enough to serve at family gatherings.

If you’re looking for more cozy dinner inspiration, try my savory honey garlic ground beef with broccoli or my one-pan favorite, smoked sausage and rice. Each one is simple, hearty, and perfect for busy nights.

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